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Shabnam Das Kar and Michal Ofer
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Insulin Resistance

June 3, 2020 by Shabnam Das Kar

Obesity, Diabetes And Covid 19

The Coronavirus disease 2019 (COVID-19) caused by the SARS CoV2 virus (Severe Acute Respiratory Syndrome Coronavirus 2 ) was first reported in China in late December, 2019. It has has since evolved into a global pandemic (present all over the world).

Quick Facts About Covid 19:

  • It is highly contagious. It can spread very easily. Unlike previous SARS viruses, the SARS CoV2 settles in the nose and throat. This means it can spread when you talk or laugh or sing, particularly in confined spaces (super-spreader events).
  • Asymptomatic spread. People may have the virus and potentially spread the disease even when they do not have symptoms of Covid 19.
  • It is a new virus. However, in a short span of 6 months, scientists have already found out quite a lot about this virus. By January 12, 2020, the virus was sequenced in China. This means that the genetic signature of the virus is known. This is important from the perspective of testing and treatment. [1]Ref
  • Vaccine: There is no vaccine against the SARS CoV2 available now, but many promising ones are in development.
  • At present, there is no specific treatment available for Covid 19. However, the search is on!
  • The Coronavirus is here to stay. It is not going anywhere. This means that measures of physical distancing will remain even after the lockdown. For how long? We do not know as yet.
  • Wearing face masks help!
  • Young people are not immune to Covid 19, particularly if they are overweight and/or have a chronic disease.
[Read more…] about Obesity, Diabetes And Covid 19

References[+]

↑1 Ref

Filed Under: Covid 19, Insulin Resistance, Weight Loss Tagged With: Covid 19, insulin resistance, Obesity, Overweight

March 19, 2020 by Michal Ofer

High Carbohydrate Food To Minimize or Avoid

While it is true that on the MDS Program we do not recommend meal plans or measuring food or counting calories, it is true that if you are insulin resistant your chances of losing weight on a low carbohydrate diet are higher.

Listen to your body. “Eat when you are hungry, drink when you are thirsty.”

In the sections below are food and drink that you may consider avoiding or minimizing.

All Sugars

  • White sugar
  • Brown sugar
  • Powdered sugar
  • Any food with added sugar
  • Processed food with added sugar
  • Junk food with added sugar
  • Jams and Preserves
  • Some Sauces (check nutritional label and ingredients)
  • Fructose (sugar in fruit)
  • Some Salad Dressings (check nutritional label and ingredients)
  • Cocoa mix
  • Molasses
  • Honey
  • Jaggery
  • High-fructose corn syrup and foods made with it
  • Syrups

Baked Goods and Sweets

  • Cookies / Biscuits
  • Cake
  • Pie
  • Brownies
  • Donuts
  • Pastries
  • Muffins

Candy

  • Chocolate Bars
  • Hard Candy
  • Milk Chocolate
  • Cotton Candy
  • And all others made with sugar

Packaged/Processed Snacks

  • Flavoured Nuts
  • Pretzels
  • Rice Cakes
  • Breakfast Bars
  • Cheese and Crackers Snacks
  • Raisins
  • Potato Chips
  • Tortilla Chips
  • Popcorn
  • Pop-tarts
  • Granola Bars
  • Twinkies
  • Cupcakes
  • “Heathy” Nut Bars
  • And other boxed snacks and products

Dairy

  • Flavoured Dairy
  • Added Sugar Dairy
  • Fruit At The Bottom or Sugar Added Yogurt
  • Whole and Skim Milk
  • Soy Milk
  • Ice Cream
  • Margarine
  • Pudding

Sugary And Starchy Fruit

High Sugar Fruit
  • Oranges
  • Kiwifruit
  • Pears
  • Pineapple
  • Plums
  • Cherries
  • Grapes
  • Figs (Also Starchy)
  • Bananas (Also Starchy)
  • Mangoes
  • Tangerines
  • Pomegranates
  • Dates
  • Applesauce
  • Dried fruit (worst choice as it has very high concentrations of sugar from the drying process)
Medium Sugar Fruit
  • Blueberries
  • Coconut Meat
  • Cantaloupes
  • Watermelons
  • Nectarines
  • Papaya
  • Peaches
  • Apples
  • Grapefruit
  • Honeydew Melons
  • Guavas
  • Apricots
Starchy Vegetables
  • White Potatoes (French fries and potato chips)
  • Sweet Potatoes or Yams
  • Corn
  • Peas
  • Squash
  • Root vegetables not advised for very low carb diets (beets, carrots, parsnips, rutabaga, turnips, butternut squash, and winter squash)

Grains And Other Starches

  • White Rice
  • Bread, Bagels and English Muffins
  • Croissants
  • Tortillas
  • Pasta
  • Cold Breakfast Cereals
  • Oatmeal
  • Cream of Wheat
  • Porridge
  • Barley
  • Amaranth
  • Millet
  • Quinoa
  • Spelt
  • Couscous
  • Bulgur
  • Rye
  • Muesli
  • Crackers
  • Pizza
  • Corn Starch
  • Pancakes
  • Waffles
  • French Toast
  • White Flour
  • Whole-Wheat Flour
  • Rice Flour
  • Corn Flour
  • All Whole Grains Too

Legumes

  • Pinto Beans
  • Black Beans
  • Kidney Beans
  • Chickpeas
  • Navy Beans
  • Lima Beans
  • Baked Beans
  • Lentils
  • Soy

Drinks

  • Soda
  • Juice
  • All Sweetened Drinks
  • Artificially Sweetened Beverages
  • Sweetened Or Flavored Tea
  • Sweetened Or Flavored Coffee
  • Frappuccino Coffee Drinks
  • Milk Shakes
  • Root Beer Floats
  • Malts
  • Frozen Coffee Drinks
  • Sports Drinks
  • Beer
  • Sweet cocktails – (Pina Colada, Daiquiri, Mai Tai, Bloody Mary, Margaritas, Screwdriver, White Russian, Rum Drinks etc.)
  • Wine coolers and alcopops

Other Articles

  • Food to Embrace
  • Food to Minimise
  • Ketogenic Diet

Filed Under: Insulin Resistance, Ketogenic Diet, Weight Loss Tagged With: Low carb Food, Weight Loss

March 5, 2020 by Michal Ofer

Intermittent Fasting Deciphered Part 1

The problem of obesity.

Why are there more overweight people now than ever before? There are a few reasons for this. Some of the reasons are included in the free eBook Why Can’t I Lose Weight?

  • The first reason is the changing diet. Far too many people are reliant on or addicted to nutrient-poor, energy-dense junk food, processed food, white flour products, etc. All these foods cause blood sugar levels to spike and this, in turn, leads to fat storage and insulin insensitivity.
  • A sedentary lifestyle is another reason. With the advent of technology, many manual tasks have become easier and less demanding.

Need to go to the supermarket that’s a 20-minute walk away? Get the car instead of walking. Need to go up to level 3 in your office building?

Take the elevator instead of the stairs. All these activities that move our bodies, use our muscles and keep things working well are avoided and replaced with easier alternatives. As a result, people are much more prone to gaining weight.

It’s so much simpler to watch TV with a bag of potato chips than to go for a run. It’s so much easier to drink a bottle of processed apple juice than eating a raw apple.

Each of these actions, no matter how small, do matter.

  • Poor quality of food. To exacerbate the situation, in much of the world, low-quality junk food is often cheaper than healthy, nutritious food. Low-income families are able to easily purchase these nutrient-depleted products but struggle to pay for “real food”. This is one of the many confounding reasons why obesity affects low-income families at a higher percentage.

One of the solutions to the problem of obesity.

There is one cure to reversing weight gain and obesity. In fact, it is so powerful that people are able to lose weight even on a junk food diet just by adopting this method. It should be noted that I never recommend consuming potentially toxic food-like substances, but this method is so powerful that it has been shown to work even in the presence of a poor diet.

Intermittent Fasting (IF)

[Read more…] about Intermittent Fasting Deciphered Part 1

Filed Under: Insulin Resistance, Intermittent Fasting, Weight Loss

March 4, 2020 by Michal Ofer

What Is The Ketogenic Diet?

The Ketogenic diet (keto) is an eating plan that features a very low intake of carbohydrates.

Why Is It Called A Ketogenic Diet?

This is called a Ketogenic Diet because this low carbohydrate diet causes your body to release ketones into the bloodstream. It pushes your body into a state called nutritional ketosis.

When you eat carbohydrates your cells utilize it for providing energy. But when you stop eating carbohydrates and get into ketosis, your body has the ability to use your body fat stores to provide ketones for fuel.

Nutritional ketosis is not to be confused with diabetic ketoacidosis, which is a serious life-threatening condition. The two are not the same.

[Read more…] about What Is The Ketogenic Diet?

Filed Under: Insulin Resistance, Weight Loss

March 2, 2020 by Shabnam Das Kar

Why Can’t I Lose Weight? Part 2 Insulin Resistance.

Insulin resistance is a condition when your cells stop responding to the insulin that is produced in your body. This is a highly simplified explanation.

Insulin is your “fat fertilizer” hormone. This is in the words of Harvard endocrinologist, Dr. David Ludwig. Most of you probably know insulin as the injection that people with diabetes (types 1 and 2) take to manage their blood glucose levels. However, here I am talking about the hormone insulin that is produced by the beta cells in your pancreas.

What Does Insulin Do In Your Body?

Insulin helps

  • In maintaining blood glucose levels in the blood.
  • Glucose to enter into the muscles.
  • Stops breakdown of fat.
  • Stimulates the liver to store glucose as glycogen.

Insulin Resistance or Metabolic Syndrome or Syndrome X?

Metabolic Syndrome has been called by various names, Syndrome X, Insulin Resistance Syndrome. It was originally called Syndrome X by Stanford Professor Dr. Gerald Reaven, who is known as the “Father of Insulin Resistance”. His 1988 Banting Lecture is legendary among those interested in this field. He passed away in February 2018 at the age of 89.

A syndrome is a group of symptoms that together are characteristic of a specific disorder or disease. In the original definition of Syndrome X, Dr. Reaven had included several criteria as shown in the image below. (Fig 1)

Criteria for Metabolic Syndrome or Syndrome X
Fig 1 Syndrome X

The common factor underlying Syndrome X is insulin resistance. The X has been dropped from the description because the relationship of insulin resistance and heart disease is no longer disputed. Now it is called Metabolic Syndrome or MetS.

Your risk for developing diabetes , dementia,stroke or heart disease is very high if you have Metabolic Syndrome.

Criteria for Metabolic Syndrome:

According to guidelines from the National Heart, Lung, and Blood Institute (NHLBI) and the American Heart Association (AHA), metabolic syndrome is diagnosed when you have at least 3 of the following 5 conditions:

  • High Fasting Blood Glucose
  • High Blood Pressure
  • High Triglycerides
  • Low HDL-C
  • Waist circumference ≥102 cm (40 in) in men or ≥88 cm (35 in) in women; if Asian, ≥90 cm (35 in) in men or ≥80 cm (32 in) in women.

Insulin Resistance/Metabolic Syndrome and Other Disease

I am stressing on this again. As you can see in the image here (Fig 2) if you have insulin resistance or MetS, your risk for many diseases increases dramatically.

Fig 2 Diseases Related To Insulin Resistance

The Relation Of Carbohydrates To Insulin Resistance

Your food is a combination of carbohydrates, fat and protein. When you eat food your insulin levels go up.

How much insulin goes up will depend on (besides other factors) the protein, fat and carbohydrate content of your food.

As you can see in the image (Fig 3) here, insulin levels are highest after a high-carbohydrate (HC) diet, followed by a high-protein (HP) diet. A high-fat (HF) diet raises insulin the least. Fasting doesn’t raise insulin levels at all.

In this study, the high-carbohydrate diet included about 60% of carbohydrates.

Fig 3 Insulin Levels after food. dit El Khoury 2006

Glycogen And Triglycerides

Fatty acids are used by fat cells to make triglycerides. Triglycerides consist of 3 fatty acids joined to a glycerol spine. When the liver is full of glycogen, any extra glucose gets diverted into making free fatty acids.

Therefore, high triglycerides in your blood is a problem of insulin resistance and carbohydrate intolerance.

It cannot be corrected by taking a cholesterol-lowering drug or by eating a diet low in good fat and high in carbohydrates. Insulin targets the heart and the lining of the blood vessels that supply the heart and brain. This is why those of you with diabetes or pre-diabetes have a high risk of heart disease, stroke and dementia.

How Will You Manage Insulin Resistance?

  • Low-carbohydrate diet. How low will depend on individual variations.
  • Eat “real food”. This does not include highly processed high carbohydrate food and sugar.
  • Time-Restricted Eating/Intermittent Fasting (TRE-IF)

Benefits Of Low-Carbohydrate Diet

As you can see in Fig 4, the effects of a low-carbohydrate diet are many. The pathways affected are numerous. Does it have to be high-fat? This will be discussed in a separate post.

Effects of Low-Carbohydrate High-Fat Diets
Fig 4 Effects of Low-Carbohydrate High-Fat Diets, Ludwig 2018

Bottom Line

  • If you have insulin resistance a low carbohydrate diet will work better for reducing weight and improving your metabolism.
  • How little carbohydrates you eat will depend on several factors. How much you exercise, sleep, your medications, genes, gut microbiome all impact your carbohydrate tolerance.

Other Articles

Why Can’t I Lose Weight Part 1

Is Intermittent Fasting Just A Low-Calorie Diet?

Filed Under: Insulin Resistance, Weight Loss

March 2, 2020 by Shabnam Das Kar

Why Can’t I Lose Weight? Part 1

Bodyweight set-point, Leptin, Insulin Resistance, Energy Balance.

Weight gain or more accurately, fat gain is a complex problem of hormones and the nervous (neuroendocrine) system. Most of you have lost weight in the past. However, did you regain all the weight? Some of you have probably reached a plateau in your fat loss. Why is that so?  In this multiple part series, I will attempt to answer these questions. We don’t have all the answers yet, but here is my effort at (hopefully) simplifying the science 

“Make everything as simple as possible but not simpler.” (Albert Einstein).

Why do I gain weight?

Complexity Of The Problem

As you can see in the graphic below, there are several factors that influence your body weight.

Complexity of obesity
Fig 1 Foresight’s Obesity Map

My goal in sharing the image above is to highlight the complexity of the problem. Something as complex as that definitely cannot be solved with solutions like “eat less and exercise more” or ” all you need is willpower” or “eat 3 meals and 3 snacks a day”.

Three Models to Explain Weight Gain

  1. Calorie-In-Calorie-Out (CICO) Model
  2. Carbohydrate-Insulin Model (CIM)
  3. Energy Balance

1) Calorie-In-Calorie-Out (CICO) Model:

You gain weight because you eat more calories than your body can utilize. Therefore if you can figure out how to eat less and move more, you will lose weight. It is only a problem of having too little willpower! How well does that work?

If you have used this plan of Eat-Less-Move-More, you know that it doesn’t work in the long term! This model assumes that fat loss is a problem of personal shortcomings.

Years of research have shown that over the long term, your body weight is controlled by biochemistry, rather than mere will power.  On a low-calorie diet, the body fights back……The Revenge of The Deprived Calorie by making you hungry and reducing your body’s Resting Energy Expenditure (more on this later).

If calories were all that mattered, then it means eating 100 calories of chicken is the same as eating 100 calories of biscuits (cookies). You know that is not true! The two are very different in terms of the metabolic response in your body.

The CICO model has been abandoned by most obesity researchers. In fact, obesity researcher, Dr. Zoe Harcombe, calls this the “psycho diet”.Unfortunately, it still has a large following amongst people who are probably not as familiar with the science (Including doctors! I was one of them until I learnt more!). 

Now, wait a minute, you are probably thinking….”But I have lost weight by counting calories and eating less and moving more, so why is she saying it doesn’t work?”

Over a short period of time, a low-calorie diet may work, but we are talking about long-term fat loss.

The Biggest Loser Study:

The Biggest Loser is a reality TV show which included contestants who struggled with extreme obesity (BMI >40). Over a period of 30 weeks, the contestant who lost the maximum amount of weight was considered the winner. They had followed the eat-less-move-more method. They lost a lot of weight over a short span of time, but over the long term, it wasn’t that great.

A follow-up study [1]Ref done after 6 years on 14 of the contestants showed that not only had they regained the weight, their metabolism had slowed down drastically.

2) Carbohydrate-Insulin Model (CIM) :

This model is based on the actions of the hormone insulin that is produced by your pancreas. According to the Carbohydrate-Insulin Model (CIM) of obesity, eating more processed, high carbohydrate and sugary food produces hormonal changes that promote fat deposition, increase hunger and reduce your metabolic rate. [2]Ref

You can see in the image below a comparison between the conventional model and the carbohydrate-insulin model of obesity.

Explanatory Models of Obesity Ludwig, 2019

You are probably familiar with the drug insulin, which is used as a prescription medication for the treatment of diabetes (Types 1 and 2). But here I am talking about the hormone insulin produced by your pancreas.

Insulin resistance is a condition where your cells become resistant to the actions of the hormone insulin. As Endocrinologist Dr. David Ludwig says, “Insulin is your fat fertilizer hormone.”

When you have insulin resistance you gain excess unhealthy fat in parts of your body like the abdomen (belly fat). Your body cannot manage your blood sugar levels well and over a period of time, you will likely develop type 2 diabetes.

Carbohydrates that you eat spike your insulin levels. Therefore, to lose weight you need to eat fewer carbohydrates than your body can tolerate. This carbohydrate tolerance level is different for each one of you. For some of you this carbohydrate tolerance level may be as low as 20-30 grams! As a reference, one apple is 20 grams of carbohydrate!

Personalised Blood Glucose Response (Video)

How will you know if you are Insulin Resistant?

Please check this infographic.

3) Energy Balance (or Energy Homeostasis)

At the centre of Figure 1 above is “Energy Balance”(I know you can’t read it clearly!). As you can see, all the different factors like food, activity, psychology etc. affect this important area.

Energy balance or homeostasis includes different biological processes that help your body maintain a specific weight. This is the bodyweight set-point.

What is the bodyweight set-point?

When you gain or lose weight, your body has the unique ability to go back to your previous weight. There are several mechanisms involving hormones, energy intake, energy expenditure and brain changes which will bring your weight back to where it was.

This bodyweight set-point applies to people who are overweight as well as to those of normal weight! You may have noticed that some of your friends have remained almost at the same weight for many years. They don’t seem to gain weight even when they eat about as much as you do! (However, they may not necessarily be healthy. Bodyweight is ONLY one measure of health).

Overfeeding studies [3]Ref done in people with obesity and lean people have shown that it is equally difficult for both to remain at a higher weight. Essentially your body defends a certain fat level, whether you are at a normal weight or have excess fat.

This is achieved by matching energy intake to energy expenditure over time. This is not as simple as it sounds. Energy balance is not merely eating food and spending food energy by exercising.

Rather than being a problem of simple passive accumulation of fat, obesity is a problem of disordered energy balance.

Leptin and Energy Balance: Should you test your leptin levels?

A few years ago one of my patients told me, “Doctor, you probably haven’t heard of this hormone called leptin.”

My know-it-all self wanted to tell her a lot of things 🙂 but fortunately, wiser counsel prevailed and I responded, “We still have a long way to go with leptin, therefore please don’t waste your money getting your blood leptin levels tested.” Why did I say that?

Leptin is a hormone produced from your fat tissue (White Adipose Tissue). The name comes from the Greek word “leptos”, meaning thin. Does it mean that leptin makes you thin? The answer is more complex than that! 

The discovery of Leptin in 1994 was a landmark in the history of endocrinology (the study of hormones). The initial enthusiasm about using leptin for the treatment of obesity did not pan out as expected. It was thought that Leptin signals the level of energy stores to the brain. Therefore, as energy stores increase in fat, leptin levels rise, thereby telling the control centres in the brain to limit obesity by reducing food intake and increasing energy expenditure.

However, the amount of circulating leptin required to affect the central nervous system differs amongst individuals. This is dependent on genes, development and diet. Some people may simply require more leptin than others.

However, studies have shown that the more body fat you have, the higher your levels of leptin.  Enter the term leptin resistance.

Leptin Resistance: Does it exist?

Just as insulin resistance causes fat gain, is there leptin resistance too? The term “leptin resistance” is often used to describe states of obesity in which high leptin levels and/or decreased responsiveness to leptin is observed. This led the National Institutes of Health to hold a workshop, “Toward a Clinical Definition of Leptin Resistance”. However, as this paper [4]Ref in the journal Cell Metabolism concludes

“……no universal, quantifiable, and clinically useful definition of the term “leptin resistance” is feasible”. It is clear that the availability of relevant human data is limited, however, and a substantial amount of new information must be acquired and disseminated to accomplish these goals.”

What is known about leptin’s actions is listed below:

  • Leptin and insulin resistance are intimately related. Therefore, if you can manage your insulin resistance well, leptin will work better too. 
  • Cortisol has important relationships with leptin. [5]Ref
  • Leptin levels are related to the amount of fat in your body. Therefore the more the body fat, the higher the levels of leptin.
  • Fasting reduces leptin levels by 50% on the first day, even before fat loss kicks in [6]Ref
  • Leptin levels are impacted by estrogens in women and male hormones (androgens) in men.
  • Leptin and fuel switch: Leptin helps in maintaining blood glucose levels during fasting. When you stop eating or when you eat very little carbohydrates, your body switches from using carbohydrates from food as fuel to using your body fat stores as fuel. Therefore, when you fast your blood sugar doesn’t go down to dangerous levels. (Caveats for those of you on anti-diabetic medications). [7]Ref
  • Leptin is linked to autoimmunity. [8]Ref
  • Leptin affects reproductive functions, bone metabolism, lipid and liver fat metabolism.
  • Using leptin as a drug helps ONLY in very rare conditions. In those with genetic defects of the leptin gene, it works dramatically. And in those people who have lipodystrophy, a condition where there is too little fat on the outside and severe insulin resistance and excessive organ fat. But that doesn’t apply to most of you.

[Important article to understand obesity (Nerd alert) [9]Ref ]

Bottom Line:

  • Obesity is a complex problem and therefore simplistic solutions like eat-less and move-more do not work over the long term.
  • Most of you with weight loss challenges are insulin resistant. If you are insulin resistant, a low carbohydrate diet and time-restricted eating will probably work better for weight loss.
  • If you are not insulin resistant ( very small percentage), then there are other areas that have to be looked into.

Other Articles :

Why Can’t I Lose Weight Part 2: Insulin Resistance?

What Is The Ketogenic Diet?

References[+]

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Filed Under: Insulin Resistance, Weight Loss

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